TUMOR-COLONIZING E. COLI EXPRESSING BOTH COLLAGENASE AND HYALURONIDASE ENHANCES THERAPEUTIC EFFICACY OF GEMCITABINE IN PANCREATIC CANCER MODELS

Desmoplasia is a hallmark feature FACTORY SECOND of pancreatic ductal adenocarcinoma (PDAC) that contributes significantly to treatment resistance.Approaches to enhance drug delivery into fibrotic PDAC tumors continue to be an important unmet need.In this study, we have engineered a tumor-colonizing E.coli-based agent that expresses both collagenas

Feature selection (FS) is an essential preprocessing step in utmost solutions for the high-dimensional problem to reduce the number of features by deleting irrelevant and redundant data that preserve a suitable grade of classification accuracy.Feature selection can be treated as an optimization problem.Heuristic optimization algorithms are hopeful